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| | Record ID | 003497 |
| | Publication type | Journal Article |
| | Title | Risk factors of accelerated liver fibrosis in HIV-HCV coinfection: a matched analysis: original |
| | Source of Record | WHO Regional Office for Africa, Library, Brazzaville, Congo |
| | Author(s) | Ibrahim, A.; Shpaner, A.; Nieto, J. |
| | Journal Title | South African Gastroenterology Review |
| | ISSN | 1812-1659 |
| | Date of publication | 2004 |
| | Volume and n° | 2(3) |
| | Pages | 14-17 |
| | Language | English |
| | Descriptor | liver diseases;
HIV;
Risk factors
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| | Abstract | INTRODUCTION: Chronic liver diseases have become a significant cause of mortality in HIV patients. Few reports have assessed risk factors for HCV disease progression in HIV infected patients. OBJECTIVES: Compare fibrosis progression rate between HIV/HCV coinfected patients and HCV only patients and identify risk factors associated with higher progression. METHODS: (18) HCV/HIV coinfected patients were matched to (59) HCV patients in a 1:3 ratio. Matching variables were 1) duration of HCV, 2) alcohol use, 3) age, 4) gender, and 5) race. Both unmatched and matched analyses were performed on fibrosis stage and progression rate (stage /Year). An ordinal logistic regression analysis was used to identify risk factors. RESULTS: Using metavir unit system, mean fibrosis rates were (0.26±0.17) and (0.111±0.09) for coinfected and HCV only respectively. Mean duration of HCV infection was (22.05±1.1) and (15.5±2.2) for coinfected and HCV only respectively. Unmatched analysis revealed a statistically significant difference in fibrosis progression rate between both groups (p=0.001). There was a statistically significant difference in the proportion of patients with stage 4 between both groups (p=.004). Ordinal Logistic Regression model (unmatched analysis) suggested that age (OR 1.13, p=0.055, CI 0.002 to 0.238), duration of HCV (OR 1.12, p=.006, CI 0.033 to 0.197), and HIV status (OR 9.60 P=0.002, CI 0.86 to 3.65) are statistically significant independent predictors of higher progression rate and higher fibrosis stage (overall model R2=.20, F=.0002). CONCLUSIONS: Duration of HCV infection, age, and HIV status are significant independent predictors of accelerated fibrosis in HIV coinfected population. HIV/HCV coinfected patients should be counseled and their providers informed regarding fibrosis progression risk factors. Further studies are needed to find the underlying biological and immunological mechanism of acceleration. |
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