Database : AIM Search on : NIGERIAN JOURNAL OF HEALTH [Journal] References found : 86 [refine] Displaying: 1 .. 20   in format [Detailed]

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Record No. 8582 Record ID 008582 Publication type Journal Article Title Periodontal Status of Adolescents in Surulere, Lagos State, Nigeria Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Umesi Koleso, D. C.; Ayanbadejo, P. O.; Savage, K. O. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 88-92 Language English Descriptor Periodontal Diseases-prevention and control; Periodontal Diseases-diagnosis; Periodontal Diseases-therapy; Adolescent Descriptor-Geographic Nigeria Abstract Objective : The objective of this study was to assess the periodontal status, treatment needs and dental visit practice of adolescents in Lagos, Nigeria. Methods : 600 subjects were selected by stratified random sampling from 6 schools, 3 secondary and 3 primary schools in Surulere Local Government Area of Lagos state, Nigeria. About one hundred subjects in each age category of 11 to 16 years were selected. A questionnaire was designed seeking biographic data such as age, sex, occupation of parent, and dental visit attendance and a section for recording periodontal clinical examination using the Community Periodontal Index of Treatment Needs (CPITN) was included. The periodontal status, treatment needs and dental visit practices of adolescents were determined. Results: Only 3 were found to be healthy periodontally. 83 of the subjects presented predominately with the worst condition recorded, code 2 (i.e. calculus), which is a reversible condition. A mean of 0.6 healthy sextants, 2.3 bleeding sextants and 3.1 calculus-accumulated sextants was calculated. A statistical difference in periodontal status was noted with age, the younger adolescents (11-13 years) presenting predominately with bleeding sextants when compared to the older adolescents (14-16 years) who presented more calculus-accumulated sextants. Nearly all subjects required periodontal treatment. 83 needed professional prophylaxis (TN2). Conclusion: There is a need for a school oral health education programme within the LGA with a focus on periodontal disease prevention and provision of oral prophylaxis by dental surgeons, therapists and volunteer dental students.

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Record No. 8581 Record ID 008581 Publication type Journal Article Title Gender Differences related to HIV/AIDS in South West Nigeria Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Uti, O. G.; Sofola, O. O. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 83-87 Language English Descriptor Gender Identity; HIV; Acquired Immunodeficiency Syndrome; Disclosure Descriptor-Geographic Nigeria Abstract The aim of this study was to determine some underlying gender differences in the pattern of infection in a group of HIV positive patients in Nigeria. It involved 328 consecutive HIV positive patients attending dedicated clinics at four teaching hospitals in the South western part of Nigeria. Information on patients' socio-demographic characteristics and their attitude towards disclosure of their HIV status were collected with an interviewer administered questionnaire. There was a significant difference in the age distribution between the genders with a higher proportion of those younger than 35 years being females and higher proportion of males in the older age groups (p 0.05). A higher proportion of the female respondents were unemployed (73.2), students (88.9) and small scale traders (62.5) compared to the males. There was also a significant difference between the genders concerning disclosure of HIV status with the males more willing to disclose their status compared to the females (p 0.05). Fear of breach of confidentiality and discrimination were the most common reasons given. Conclusion: There is a need for economic empowerment of women as poverty increases the vulnerability of women to the infection.

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Record No. 8580 Record ID 008580 Publication type Journal Article Title The Prevalence of Oral Habits Among 4 to 15 year Old School Children in Lagos Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Quashie-Williams, R.; Dacosta, O. O.; Isiekwe, M. C. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 78-82 Language English Descriptor Habits; Prevalence; Child; Schools Descriptor-Geographic Nigeria Abstract Objective: To provide information regarding the prevalence of oral habits among a group of Nigerian children. Study Design : This is cross-sectional study of 928 children, 431 males and 497 females aged 4 to 15 years from both rural and urban areas of Lagos State in Nigeria. Habits assessed included digit, lip and tongue habits. Results: Thirty four point one per cent of the children examined presented with an oral habit. Of these, digit sucking was the most frequently occurring, seen in 50 of the children with oral habits. Tongue and lip habits occurred in 27 and 23 of children respectively. There was observed a steady decrease in oral habits with an increase in age. The prevalence being highest among 4 to 5 year olds (44.2) and gradually decreasing to 11.8 among the 14 to 15 year age group. Oral habits were found to be slightly more common among males than females, though this finding was not significant. Socio-economic status (SES) was found to have a significant effect on the occurrence of oral habits. Forty eight per cent of all children of high SES engaged in an oral habit, whereas this was observed in only 24.4of all children of low SES. Conclusion : The findings of this study indicate that there is an increased prevalence of oral habits among children in the population in recent times. The occurrence of these habits is more frequently seen in children from families of high socio-economic status.

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Record No. 8579 Record ID 008579 Publication type Journal Article Title The Correlation Between Ultrasound-Measured Fetal Heart Rate and Gestational Age in a Normal Pregnant Nigerian Population Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Eze, U. C.; Okaro, A. O. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 73-77 Language English Descriptor Heart Rate, Fetal; Gestational age; Pregnant Women Descriptor-Geographic Nigeria Abstract A total of 400 apparently healthy pregnant women with singleton fetuses from Enugu, Southeast Nigeria were randomly selected for the study. The aims of the study are to establish : a normogram for fetal heart rate (FHR) and the relationship between fetal heart rate and gestational age (GA) by 2-D ultrasound. Crown rump length measurement was used for estimating GA in the first trimester while femur length and biparietal diameter measurements were used for estimating GA in the second and third trimesters. Result shows that the normal range of FHR was 120 to 162 beats per minute (BPM). There was a statistically significant negative correlation of FHR with GA in the first, second, third and combined trimesters as the coefficient of correlation, r = -0.652, -0.736, -0.8185 and -0883 respectively. The study shows that a unit increase in GA decreases the FHR by 32, 15, 12.6 and 13 in the first, second, third and combined trimesters respectively. Results suggest that FHR measurement should be done routinely as one of the essential parameters for the assessment of fetal well being by ultrasound.

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Record No. 8578 Record ID 008578 Publication type Journal Article Title Safety Awareness in Selected X-ray Diagnostic Centres in Surulere and Ikeja Local Government Areas of Lagos State, Nigeria. Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Aweda, M. A.; Awosanya, G. O. Journal Title Nigerian Journal of Health and Biomedical Sciences Date of publication 2007 Volume and n° 6(1) Pages 62-72 Language English Descriptor Equipment Safety; Radiology; X-Rays Descriptor-Geographic Nigeria Abstract Background: Health hazards are associated with exposure to ionizing radiations such as x-rays. Many private x-ray diagnostic clinics in Lagos State operate with inadequate safety and protection devices, which make the conditions unsafe to patient and environment. Objective: To assess the working conditions, protection measures put in place, safety awareness and attitudes of both employees and employers to safety and protection in radiodiagnostic centers in Surulere and Ikeja Local Government Areas.Methodology: Questionnaires were used for collecting information on socio-demographic data, occupational history, activities, working conditions, knowledge and experience of radiation hazards in x-ray centers. Interviews were conducted with Heads of Departments and Radiologists using the checklist adapted from the International Atomic Energy AgencyResults: 88.9 of the participating centers had adequate space and some safety assessment performed prior to installation of the facility. 81.5 had few basic protection devices. Only 40.7employed adequate and qualified staff while 25.9 provided personnel training and 22.2 had quality control programme. 14.8 had radiation protection programme. 60.2of respondents were aware of health hazards associated with radiation exposures, 57.8 of which were males. Conclusion : Operation conditions in most private diagnostic centers are below standard due to grossly inadequate provision of safety and protection devices. Employment of qualified staff and continuous education need be emphasized and enforced

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Record No. 8577 Record ID 008577 Publication type Journal Article Title Mortality rate in Sickle Cell Disease Patients in Crisis at a Haematology Day Care Unit (HDCU) in Nigeria Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Olabode, J. O.; Shokunbi, W. A . Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 63-66 Language English Descriptor Hemoglobin SC Disease; Mortality; Patients Descriptor-Geographic Nigeria Abstract The Haematology Day Care Unit (HDCU) of the University College Hospital, Ibadan, Nigeria was established in 1975 with the main goal of providing immediate and specialized care to haematological emergencies, particularly sickle cell disease (SCD) patients. Since inception, a systematic analysis of its effectiveness has not been done, hence this study. A retrospective study of all registered patients attending the Haematology Day Care Unit of the University College Hospital, Ibadan, over a one-year period was conducted and analyzed. Demographic data, diagnosis, treatment received, outcome of such treatment as well as laboratory parameters were extracted from HDCU register and the data were then analysed using descriptive statistics. A total of 890 patients were seen during the period, January and December 2001, out of which 520 were sickle cell disease patients (HbSS accounted for 508 (92.7) cases and HbSC, 40 (7.3) cases). The mean age of the SCD patients was 25.8years, the median, 23years and the mode, 18years. The mean PCV was 21.2, median, 21.0 and mode, 20. Majority (246 or 47.3) of the patients were between 20 and 30 years, the lowest frequency being in the 50years group (14 or 2.7). One patient died during the period under review (31year old female with HbSC disease), giving a mortality rate of 2 per 1000 patients

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Record No. 8576 Record ID 008576 Publication type Journal Article Title A Review of Chest Pain in Nigerian Hypertensive Patients Presenting to the Out-Patient's Clinic of a Teaching Hospital Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Oke, D. A. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 58-62 Language English Descriptor Chest Pain-epidemiology; Hypertension-epidemiology; Ambulatory Care Facilitie Descriptor-Geographic Nigeria Abstract In a prospective 6-month study, chest pain was reviewed in hypertensive man above 40 years and post menopausal women on antihypertensive therapy. The subjects were made up of 230 volunteers made up of 101 males and 129 females. Their mean age was 54.5 + 10 years (males 51.3 + 8.9 years vs. female 53.3 + 9.8 years). Forty seven percent of subjects admitted to pain as being located in the retrosternal area, in 38 it was cited at the precordial area and the remainder (9) cited the pain on the right side of the chest and 6 submamary. Twenty six percent and 22 of subjects described pain as being pressure like or dull consecutively. In 42 of patients pain was aggravated by exertion, in 32 of subjects pain had no aggravating factor, 14 and 3 had pain aggravated by hunger and the use of non steroidal anti-inflammatory agents. In the remaining 9 pain was aggravated by breathing particularly during the inspiratory phase of respiration. The relieving factors described include rest in 34, analgesia in (25), change of position in 4 and antacid in 12. In the remaining 25 no relieving factor was identified. Pain radiation was described was mainly to the epigastrium. Based on the symptoms, 11 had all the three parameters of pain description suggestive of angina pectoirs. 5 of patients had symptom suggestive of atypical angina and 17 had just one character present and considered non cardiac. The difference in serum cholesterol level in patients described as having classic angina and atypical were statistically significantly higher than those in subjects who did not complain of chest pain. Patients with atypical chest pain had the highest blood pressure; those with non cardiac pain had the highest WHR while those with no pain had the highest BMI. A proper approach to patients with chest pain irrespective of how trivial it may seem, should include a careful description and characterization of the chest pain, careful and a thorough physical examination. A rational and judicious utilisation of facilities should be employed carrying out the available investigations and possibly following chest pain protocols. .

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Record No. 8575 Record ID 008575 Publication type Journal Article Title Laboratory Survey of Significant Bacteriuria in a Family Practice Clinic - Is the Spectrum of Causative Agents Changing? Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Oduyebo, O. O.; Ayankogbe, O. O.; Adedokun, A. A.; Ogunsola, F. T. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 52-57 Language English Descriptor Urinary Tract Infections-therapy; Bacteriuria Drug Resistance Spectrum Analysis Laboratories Abstract Urinary tract infection correlates with significant bacteriuria. Empiric and definitive therapy depends on the sensitivity pattern of the causative agents, so it is essential to keep abreast of changes in the causative organisms. This study was carried out to determine the causative agents of significant bacteriuria and their antibiotic sensitivity pattern. Mid stream urine specimens were collected from all patients attending the Family Medicine Clinic of the Lagos State University Teaching Hospital, Ikeja Lagos in July and August of 2005. The urine specimens were transported on ice to the Medical Microbiology and Parasitology Department of the College of Medicine, Idi-Araba. Significant bacteriuria was determined by the standard loop method. Culture was performed on MacConkey agar (oxoid) and blood agar base (Oxoid) and Isolates were identified by standard laboratory methods. Antibiotic sensitivity was by disc diffusion method. Four hundred and fifty urine specimens surveyed for bacteria were from 251 females (55.8) and 199 males (44.2) with age range 13 to 89 years. Ninety four patients (20.9) had significant bacteriuria and 14 were symptomatic, making the prevalence rate of symptomatic bacteriuria 3.1. Out of 91 patients who had been on antibiotics, a significantly higher proportion (52) had bacteriuria while only 13.4 of those who had not been on antibiotics had bacteriuria. Klebsiella and Enterobacter species were more commonly isolated than E. coli. Most of the isolates were resistant to cotrimoxazole (89), tetracycline (69.1) and amoxicillin (88.1) and amoxicillin (88.1). Sensitivity rates to the urinary antiseptics ranged from 54.2 to 55.9. Many of the bacteria were sensitive to ofloxacin (92.9)), ciprofloxacin (84.7), cefotaxime(72.9), ceftriaxone(86.4) and ceftazidime( 88.1). Sensitivity to the aminoglycosides ranged from 57.7 to 59.3

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Record No. 8574 Record ID 008574 Publication type Journal Article Title Analysis of Fallopian Tubes seen in the Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria:- An Histopathological Survey Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Izegbu, M. C.; Amole, O. O.; Shittu, L. A. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6 (1) Pages 49-51 Language English Descriptor Fallopian Tubes-physiopathology; Salpingitis Pregnancy, Tubal Abstract OBJECTIVE: The aim of this study is to appraise the major diseases of the fallopian tubes and causes of damage in this environment. MATERIALS AND METHODS: A retrospective study of a 4-year review of consecutive fallopian tube specimens received at the Department of Morbid Anatomy of the Lagos State University Teaching Hospital (LASUTH), Ikeja, Lagos, conducted between 1st of May, 2001 and 31st July, 2005. RESULTS: Over the study period, a total of 237 fallopian tubes were studied. The ages of the patients range from 18 to 54 years with the peak incidence in the 21 to 30 years with the median age of 26. 85(46.4) of the specimens received from 183 patients had ages indicated. Ectopic pregnancy is the commonest indication for sending fallopian tubes to the laboratory for investigation in 63.9 of cases. No case of cancer of the fallopian tubes or tuberculous salpingitis was seen in this study. CONCLUSION: Tubal pregnancy is the commonest indication for sending fallopian tubes to the laboratories for analysis in 63.9 of cases. Malignant tumours of the fallopian tubes and tuberculous salpingitis are rare in this environment.

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Record No. 8573 Record ID 008573 Publication type Journal Article Title The Effects of Lateral Wedge Insole in the Management of Patients with Varus Osteoarthritis of the Knee Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Akinbo, S. R.; Iko, A. O. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 35-37 Language English Descriptor Osteoarthritis-diagnosis; Patellofemoral Pain Syndrome Disability Evaluation Therapeutics Descriptor-Geographic Nigeria Abstract Although insufficient evidence supports the application of lateral wedge insole (LWI) as a non-operative treatment for medial/varus osteoarthritis of the knee joint, objective evaluation of its effects on pain, stiffness and functional disability is limited. The purpose of the study therefore was to determine the effect of LWI on the functional disability and symptoms resulting from the medial/varus osteoarthritis of the knee.Fifty (50) out of 76 patients referred for physiotherapy with diagnosis of varus osteoarthritis of the knee joint participated in this study. The 50 subjects were randomly assigned into 2 groups of 25 patients each. Group A (Experimental), were treated with thermal therapy, massage and LWI. Group B (Control), were treated with thermal therapy and massage only. The outcome measures included knee pain, knee stiffness and functional disability. These parameters were statistically analysed pre and post treatment.Results established a significant difference (p0.05) post treatment between the 2 groups for the outcome measures except knee stiffness. It can be inferred from the results that the therapeutic reduction in pain intensity and enhanced physical activities in group A compared with group B was induced by the LWI.These results provide some insight into the functional effects of the LWI on pain, knee stiffness and functional disability of patients with medial osteoarthritis of the knee. This makes the LWI a useful treatment modality in the management of varus osteoarthritis/varum gonarthrosis.

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Record No. 8572 Record ID 008572 Publication type Journal Article Title Pathological Changes Induced by Chrysobalanus Icaco Seeds Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Edema, M. O.; Omogbai, E. K.; Afijabi, S. A.; Idaewor, P. E. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Language English Descriptor Chrysobalanaceae; Cholesterol; Alkaline Phosphatase; Aspartate Aminotransferase, Cytoplasmic; Alanine Transaminase Descriptor-Geographic Nigeria Abstract The study was to determine possible pathological changes induced by the consumption of C. icaco and possible health implication. Animal feed tests were carried out using varying amounts of the seed mixed with usual mice meals. The result revealed weight loss, and increase in total bilirubin, protein, albumin, globin, cholesterol level, alkaline phosphate and mean serum glutamic - oxaloacetate transaminase and serum glutamic - pyruvic transaminase activities. Possible health implications are discussed.

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Record No. 8571 Record ID 008571 Publication type Journal Article Title Plasma Ascorbic Acid and Non-Enzymatic Antioxidants Level in Unoperated Cataract Patients Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Olisekodiaka, M. J.; Adedoyin, A.; Onuegbu, A. J.; Ebesunun, M. O.; Agbedana, E. O. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1995-7262 Date of publication 2007 Language English Descriptor Ascorbic Acid; Antioxidants; Cataract; Free Radicals; Oxidative Stress Abstract Free radicals have been implicated in the pathology of several diseases including cataract. Ascorbic acid functions as the major chain breaking antioxidant vitamin in the aqueous phase. Bilirubin, albumin and uric acid are regarded as natural antioxidants. There are conflicting reports on plasma concentrations of these antioxidants in cataract patients. 89 subjects consisting of 55 cataract patients and 34 control subjects were recruited for the study. The mean age of the subjects was 61± 11yrs. Mean plasma ascorbic acid level was significantly lower in cataract patients (0.33± 0.27) when compared with age matched control group (0.59 ±0.37) (p 0.05). A significant increase in mean plasma bilirubin was observed in cataract patients when compared to the corresponding controls. Plasma uric acid levels showed a positive correlation with ascorbic acid (r

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Record No. 8570 Record ID 008570 Publication type Journal Article Title Comparative Studies of Antimicrobial Properties of Cardiospermum Gradiflorum and Cardiospermum Halicacabum Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Banso, A. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 31-24 Language English Descriptor Anti-Infective Agents; Sapindaceae; Plant Extracts; Candida albicans; Escherichia coli; Staphylococcus aureus; Bacillus subtilis; Viridans Streptococci Descriptor-Geographic Nigeria Abstract Extracts of Cardiospermum gradiflorum and Cardiospermum halicacabumwere screened for antimicrobial activities against Candida albicans, Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Streptococcus viridans using the agar diffusion method. The two plants produced antimicrobial activities against all the test organisms. C. grandiflorum exhibited higher antimicrobial activity than C. Halicacabum. S.aureus was the most resistant to the extract of C. Gradiflorum among the organisms assayed while E. coli was the most resistant to the leaf extract of C. halicaca. The mimumum inhibitory concentration of the extracts ranged between 35mg/ml and 50mg/ml. Cardiospermum Gradiflorum could be a more effective antimicrobial agent than Cardiospermum halicaca.

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Record No. 8569 Record ID 008569 Publication type Journal Article Title Azadirachta indica (Neem) Seed Extracts : A Supplement for Culture Medium for Growth of Aspergillus niger Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Adekunle, O. C. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 29-30 Language English Descriptor Azadirachta; Aspergillus niger; Plant Extracts; Culture Media; Seeds Abstract The effectiveness of Neem seed extracts (Azadirachta indica A. Juss) was tested against Aspergillus niger isolated from soil to determine whether the neem seed extracts will inhibit or enhance the growth of Aspergillus niger. Three different concentrations of neem seed extracts were prepared 10, 20 and 50. The results showed that the neem seed extracts enhanced the growth of Aspergillus niger from 24 hours of incorporation up to 120 hours. The growth enhancement was also found to increase with concentration of the seed extracts.

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Record No. 8568 Record ID 008568 Publication type Journal Article Title Effects of Tea Consumption on Plasma Lipids and Lipoproteins in Apparently Healthy Individuals Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Onuegbu, A. J.; Fawekun, H. A.; Olisekodiaka, M. J.; Ebesunun, M. O.; Ikaraoha, I. C.; Agbedana, E. O. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Language English Descriptor Tea; Cholesterol, LDL; Cholesterol, HDL; Lipoproteins; Health Descriptor-Geographic Nigeria Abstract Possible alterations in total plasma cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol concentrations were studied in forty healthy human subjects (twenty-two males and eighteen adult females) after twenty eight days of tea consumption. A commercial brand of tea preparation was drunk by each of the subjects and they were made to take two standard cups (4.0g) of tea infusion per day. The result showed a significant decrease in mean HDL-cholesterol and increase in LDL-cholesterol concentrations compared with the mean control values. The mean total cholesterol was statistically unchanged. When the subjects were grouped into males and females, the mean LDL-C concentration was significantly elevated in both male and female groups while the mean HDL-C and triglyceride levels only in female subjects when compared with the corresponding control group. The difference observed in the value of the mean total cholesterol was not statistically significant in individual male and female groups.Findings from this study suggest that tea consumption could affect the metabolism of atherogenic lipid fractions and may thus be important in the aetiology of coronary heart disease

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Record No. 8567 Record ID 008567 Publication type Journal Article Title Evaluation of Serum Testosterone Levels as Immuno-Enhancer in Nigerian Woman Positive to Autoanti-microsomal Antibodies and Experiencing Secondary Infertility and Spontaneous Abortion Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Oladimeji, O. S.; Bankole, H. A.; Magbagbeola, O. A.; Akinwande, I. A. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6 (1) Pages 21-24 Language English Descriptor Testosterone; Pregnancy; Infertility; Abortion, Spontaneous; Women Descriptor-Geographic Nigeria Abstract In this study, One hundred and forty-eight (148) healthy euthyroid Nigeria women, all volunteers were grouped into two (2) sets of seventy four (74) in the test (subjects) and control groups. The Anti-thyroperoxidase (anti TPO) antibody, ELISA assay carried out showed that 20 (58) of the secondary infertile and 33 (82) of the spontaneous abortion groups have the anti TPO titer mean value of 22.09+ 11.74 units/ml and 54.91 + 7.64 units/ml respectively. These were compared with anti TPO titer mean value from 9 (26) non pregnant- Nulligravida and 10 (25) pregnant with 28.83+ 2.50unit/ml and 11.87+ 1.52 units/ml respectively. The students t-test statistical analysis at p0.05 showed that there was statistical significance in the differences.There was high level of testosterone titer above the male range in all the categories of women positive to anti TPO antibody. However, the secondary infertile group with the testosterone titer mean value of 3.03 + 0.33 ng/ml showed no significant difference when compared with the pregnant and non-pregnant -nulligravidae control having testosterone titer mean value of 5.37+ 0.42ng/ml and 1.03 + 0.46 ng/ml respectively. Conversely there was statistical significant differences when the testosterone titer mean value of the spontaneous abortion group of 10.81+ 5.55gn/ml was compared with that of the control non-pregnant Nulligravidae of 1.30 + 0.46 ng/ml and pregnant of 5.37+ 0.42ng/ml at p 0.05. This thus showed that the observed increase in the serum free testosterone level in women with anti TPO antibody was significant and may vary with different physiological conditions in women.

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Record No. 8566 Record ID 008566 Publication type Journal Article Title Sub-chronic Toxicity Studies of the Aqueous Leaf Extract of Rauvolfia Vomitoria (Afzel) Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Amole, O. O.; Izegbu, M. C. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6 (1) Pages 18-20 Language English Descriptor Rauwolfia-toxicity; Plant Extracts Animal Experimentation Rats Descriptor-Geographic Nigeria Abstract The cumulative effects of the aqueous leaf extracts of Rauvolfia vomitoria on body tissues was studied. Six groups of male rats consisting of 5 rats per group were given doses of the leaf extract ranging from 0.03g kg-1-1.2g kg-1 to drink at will from their drinking bottles for 42 days. During the period of the study, weights of the animals were monitored weekly with their gross appearances. At the end of the 42nd day, the rats were killed by cervical dislocation. Post-mortem of each of the animals was performed. The liver, kidney, stomach, heart and lungs were excised. The organs from the groups given plant extract were compared with those of the controls. Body weight of both the treated and the control animals rose progressively as the period increased. The pathological features like oedema and hypertrophy noticed in the tissues are considered to be of no serious consequence as they disappeared after cessation of therapy. There abnormalities may possibly not develop with R. vomitoria used for a short period. It is therefore, considered to be non-hazardous.

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Record No. 8565 Record ID 008565 Publication type Journal Article Title Evaluation of Mineral and Amino Acid Composition of Leaves of Ocimum Gratissimum (L.) Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Egesie, U. G.; Adelaiye, A. B.; Egesie, O. J. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6(1) Pages 15-17 Language English Descriptor Ocimum; Minerals; Amino Acids; Evaluation Descriptor-Geographic Nigeria

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Record No. 8564 Record ID 008564 Publication type Journal Article Title Changes in Testes Lipid Profile in Rats Fed on Thermally-Oxidized Soya bean Oil-Based Diets Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Ayelagbe, O.G.; Iyanda,; Onuegbu, A. J.; Olisekodiaka, M. J.; Adekunle, A. S.; Opaleye, O. O. Journal Title Nigerian Journal of Health and Biomedical Sciences ISSN 1595-8272 Date of publication 2007 Volume and n° 6 (1) Pages 10-14 Language English Descriptor Testis; Dietary Fats, Unsaturated; Soybean Oil; Fatty Acids, Essential; Phospholipids; Growth; Fatty Acids, Essential Descriptor-Geographic Nigeria Abstract The effect of thermally-oxidized soyabean oil-based diets on the lipid profile of the testes of rats was studied. For 35 days, two groups of male weanling rats were fed a basal diet containing unoxidised and oxidized soyabean oil. Rats fed the thermally oxidized soyabean oil diets displayed typical signs of essential fatty acids (EFA) deficiency and had their testes weights reduced to about 81 of fats fed unoxidised soyabean oil diets. There was a significant decrease (p0.05) in phosphatidylcholine and diphosphatidylglycerol content and increase in cholesterol (p0.005) content of the testes of rats fed oxidized soyabean oil-based diet compared to those fed unoxidised oil diets.

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Record No. 8563 Record ID 008563 Publication type Journal Article Title Effect of Aqueous Extract of Alstonia Congensis on Glucose Transport and Na+-K+-ATPase Activity in the Everted and Non-Everted Guinea Pig Intestine and Erythrocyte Fragility Source of Record WHO Regional Office for Africa, Library, Brazzaville, Congo Author(s) Akinwande, A. I.; Adeyemi, O. A.; Odiri, B. O. Journal Title Nigerian Journal of Health and Biomedical Sciences Date of publication 2007 Volume and n° 6 (1) Pages 5-9 Language English Descriptor Alstonia; Plant Extracts; Glucose Transport Proteins, Facilitative; Na(+)-K(+)-Exchanging ATPase; Erythrocytes Descriptor-Geographic Nigeria Abstract The seed of Alstonia congensis has been used as purgative by traditional doctors. It is not known if glucose transport and Na+-K+ ATPase activity are affected during the purging process. The effect of the plant on erythrocytes fragility is also not known. This study was designed to provide this information. The effect of aqueous extract (1:25w/v) of Alstonia congensis on the transportation of glucose ranging from 0.10 to 0.40M from normal and everted guinea pig intestinal strips into the surrounding 0.5M TrisEDTA saline buffer pH 8.2; on Na+-K+- ATPase activity and erythrocytes fragility were measured. Results showed that the aqueous extract reduced glucose transportation; inhibited Na+-k+-ATPase activity and specific activity at higher enzyme protein concentration and activated the enzyme activity and specific activity at lower enzyme protein concentration. Glucose transport reduction was linked to the effect of the extract on the Na+-k+-ATPase system. The extract also increased erythrocytes fragility. The active ingredient(s) in the extract is not known yet and research work is in progress to ascertain it.

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