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| | Record ID | 011010 |
| | Publication type | Journal Article |
| | Title | The Acute Inflammatory Response in Trauma / Hemorrhage and Traumatic Brain Injury: Current State and Emerging Prospects |
| | Source of Record | WHO Regional Office for Africa, Library, Brazzaville, Congo |
| | Author(s) | Namas, R.; Ghuma, A.; Hermus, L.; Zamora, R.; Okonkwo, D. O.; Billiar, T. R.; Vodovotz Y |
| | Journal Title | Libyan Journal of Medicine |
| | ISSN | 1819-6357 |
| | Place of Publication | Tripoli |
| | Publisher | Ibnosina Medical Association |
| | Date of publication | 2009 |
| | Volume and n° | 4(3) |
| | Pages | 97-103 |
| | Language | English |
| | Descriptor | Wounds and Injuries;
Shock, Hemorrhagic;
Systems Biology
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| | Descriptor-Geographic | Libya
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| | Abstract | Traumatic injury/hemorrhagic shock (T/HS) elicits an acute inflammatory response that may result in death. Inflammation describes a coordinated series of molecular, cellular, tissue, organ, and systemic responses that drive the pathology of various diseases including T/HS and traumatic brain injury (TBI). Inflammation is a finely tuned, dynamic, highly-regulated process that is not inherently detrimental, but rather required for immune surveillance, optimal post-injury tissue repair, and regeneration. The inflammatory response is driven by cytokines and chemokines and is partially propagated by damaged tissue-derived products (Damage-associated Molecular Patterns; DAMP's). DAMPs perpetuate inflammation through the release of pro-inflammatory cytokines, but may also inhibit anti-inflammatory cytokines. Various animal models of T/HS in mice, rats, pigs, dogs, and non-human primates have been utilized in an attempt to move from bench to bedside. Novel approaches, including those from the field of systems biology, may yield therapeutic breakthroughs in T/HS and TBI in the near future. Key words: Trauma, Hemorrhagic Shock, Taumatic Brain Injury, Inflammation, Systems Biology |
| | Electronic Access : | Full Text-1
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