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Add the result to your basket Refine your searchSerum cholinesterase level as a biomarker in detecting liver injury in Patients with chronic hepatitis c / Salem Soliman Ahmed Salama
Title : Serum cholinesterase level as a biomarker in detecting liver injury in Patients with chronic hepatitis c Authors: Salem Soliman Ahmed Salama, Author ; Bahy El-Deen El-Sayed El-Bahnasawy, Author ; Mahmoud Abd Ellatif Hashish, Author ; Mustafa Mohammed Mustafa Al Ebiary, Author Publisher: Cairo [Egypt] : Pan Arab league of continuous medical education Publication Date: 2019 Series: The Egyptian Journal of Hospital Medicine, ISSN 2090-7125 No. 76(7) Pagination: p.4662-4668, tab. Layout: Journal Article ISSN (or other code): 1687-2002 Languages : English Keywords: Cholinesterases Serum Liver Hepatitis C virus Egypt – Cairo Abstract: Background: hepatitis C virus can cause both acute and chronic hepatitis. The acute process is self-limited, rarely causes hepatic failure and usually leads to chronic infection. Chronic HCV infection often follows a progressive course over many years and can ultimately result in cirrhosis, HCC and the need for liver transplantation. Objective: the aim of this study is to evaluate serum cholinesterase (CHE) level as a biomarker for detecting liver damage in patients with chronic hepatitis C. Patients and Methods: the current study was carried out on 50 subjects selected from the outpatient's clinic of Internal Medicine Department of Sayed Galal Hospital, Al-Azhar University and admitted to the internal department. The study was performed in the period between July-2014 to July -2019. Results: Sensitivity of cholinesterase is 100%, its specificity is 100% and its accuracy is 100%, in predicting liver injury in patients with chronic hepatitis C. Cholinesterase is positively correlated with Hb, platelets and albumin. Cholinesterase is negatively correlated with ALT, AST and ALP, total & direct bilirubin, PT, INR, urea, creatinine and AFP. There is significant increase of cholinesterase among compensated compared with decompensated cirrhotic patients. There is significant decrease of cholinesterase among compensated cirrhotic patients compared with controls. There is significant decrease of cholinesterase among decompensated cirrhotic patients compared with controls. Conclusion: cholinesterase is an excellent biomarker of cirrhosis with good sensitivity and specificity. Cholinesterase shows good correlation with albumin, PT, INR and Child-Puch score. Cholinesterase distinguishes decompensated cirrhosis from compensated cirrhosis well.
Serum cholinesterase level as a biomarker in detecting liver injury in Patients with chronic hepatitis c [] / Salem Soliman Ahmed Salama, Author ; Bahy El-Deen El-Sayed El-Bahnasawy, Author ; Mahmoud Abd Ellatif Hashish, Author ; Mustafa Mohammed Mustafa Al Ebiary, Author . - Cairo (Egypt) : Pan Arab league of continuous medical education, 2019 . - p.4662-4668, tab. : Journal Article. - (The Egyptian Journal of Hospital Medicine, ISSN 2090-7125; 76(7)) .
ISSN : 1687-2002
Languages : English
Keywords: Cholinesterases Serum Liver Hepatitis C virus Egypt – Cairo Abstract: Background: hepatitis C virus can cause both acute and chronic hepatitis. The acute process is self-limited, rarely causes hepatic failure and usually leads to chronic infection. Chronic HCV infection often follows a progressive course over many years and can ultimately result in cirrhosis, HCC and the need for liver transplantation. Objective: the aim of this study is to evaluate serum cholinesterase (CHE) level as a biomarker for detecting liver damage in patients with chronic hepatitis C. Patients and Methods: the current study was carried out on 50 subjects selected from the outpatient's clinic of Internal Medicine Department of Sayed Galal Hospital, Al-Azhar University and admitted to the internal department. The study was performed in the period between July-2014 to July -2019. Results: Sensitivity of cholinesterase is 100%, its specificity is 100% and its accuracy is 100%, in predicting liver injury in patients with chronic hepatitis C. Cholinesterase is positively correlated with Hb, platelets and albumin. Cholinesterase is negatively correlated with ALT, AST and ALP, total & direct bilirubin, PT, INR, urea, creatinine and AFP. There is significant increase of cholinesterase among compensated compared with decompensated cirrhotic patients. There is significant decrease of cholinesterase among compensated cirrhotic patients compared with controls. There is significant decrease of cholinesterase among decompensated cirrhotic patients compared with controls. Conclusion: cholinesterase is an excellent biomarker of cirrhosis with good sensitivity and specificity. Cholinesterase shows good correlation with albumin, PT, INR and Child-Puch score. Cholinesterase distinguishes decompensated cirrhosis from compensated cirrhosis well.
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Title : Comparison of the effect of nitroglycerin, magnesium sulphate and dexmedetomidine as hypotensive agents in lumbar spine surgery Authors: Helal Ahmed Osama, Author ; Tawfik Mohamed Nour-Eldin, Author ; Ali Waheed Mohamed, Author ; Marwa Ali Abd El Zaher, Author Publisher: Cairo [Egypt] : Pan Arab league of continuous medical education Publication Date: 2019 Series: The Egyptian Journal of Hospital Medicine, ISSN 2090-7125 No. 76(7) Pagination: p.4628-4638, tab. Layout: Journal Article ISSN (or other code): 1687-2002 Languages : English Keywords: Nitroglycerin Magnesium Sulfate Dexmedetomidine Antihypertensive Agents Lumbar surgery Egypt – Cairo Abstract: Background: in orthopedic procedures more blood is lost from raw bone and muscle surface than from identifiable blood vessels. Moderate hypotensive anesthesia was found to significantly decrease the average blood loss by nearly 40%, reduce the need for transfusion by 45% and shorten the average operating time by nearly 10%. Objective: The aim of the current study was to compare magnesium sulphate and dexmedetomidine with nitroglycerin as regard hypotensive effect as primary outcome, volume of blood loss, blood substitution and pattern of recovery as secondary outcome during lumbar spine surgery. Patients and Methods: This prospective, controlled, comperative, randomized, double blind study included a total of ninty patients aged 21-50 years of both sex, ASA I-II scheduled for elective lumber spine surgery, attending at Department of Orthopedic, AL-Azher university Hospital in Assuit as single center study. Patients have received either dexmedetomidine, magnesium sulfate or nitroglycerine. Results: There were highly significant difference (P <0.000) with duration of surgery between different study groups with duration of surgery shortest in dexmedetomidine group followed by magnesium sulfate group and then nitroglycerine group. There were highly significant differences between different study groups with fluid maintenance with higher volume in nitroglycerine group then magnesium sulfate group and then dexmedetomidine group. There were highly significant differences (P <0.000) with systolic blood pressure between study groups at A1 and hypotensive agent discontinuation with lowest systolic blood pressure in dexmedetomidine group followed by magnesium sulfate group and then nitroglycerine group. Conclusion: nitroglycerine, magnesium sulfate and dexmedetomidine could induce hypotension, but dexmedetomidine showed more favorable hemodynamic profile as regard blood pressure and heart rate. Comparison of the effect of nitroglycerin, magnesium sulphate and dexmedetomidine as hypotensive agents in lumbar spine surgery [] / Helal Ahmed Osama, Author ; Tawfik Mohamed Nour-Eldin, Author ; Ali Waheed Mohamed, Author ; Marwa Ali Abd El Zaher, Author . - Cairo (Egypt) : Pan Arab league of continuous medical education, 2019 . - p.4628-4638, tab. : Journal Article. - (The Egyptian Journal of Hospital Medicine, ISSN 2090-7125; 76(7)) .
ISSN : 1687-2002
Languages : English
Keywords: Nitroglycerin Magnesium Sulfate Dexmedetomidine Antihypertensive Agents Lumbar surgery Egypt – Cairo Abstract: Background: in orthopedic procedures more blood is lost from raw bone and muscle surface than from identifiable blood vessels. Moderate hypotensive anesthesia was found to significantly decrease the average blood loss by nearly 40%, reduce the need for transfusion by 45% and shorten the average operating time by nearly 10%. Objective: The aim of the current study was to compare magnesium sulphate and dexmedetomidine with nitroglycerin as regard hypotensive effect as primary outcome, volume of blood loss, blood substitution and pattern of recovery as secondary outcome during lumbar spine surgery. Patients and Methods: This prospective, controlled, comperative, randomized, double blind study included a total of ninty patients aged 21-50 years of both sex, ASA I-II scheduled for elective lumber spine surgery, attending at Department of Orthopedic, AL-Azher university Hospital in Assuit as single center study. Patients have received either dexmedetomidine, magnesium sulfate or nitroglycerine. Results: There were highly significant difference (P <0.000) with duration of surgery between different study groups with duration of surgery shortest in dexmedetomidine group followed by magnesium sulfate group and then nitroglycerine group. There were highly significant differences between different study groups with fluid maintenance with higher volume in nitroglycerine group then magnesium sulfate group and then dexmedetomidine group. There were highly significant differences (P <0.000) with systolic blood pressure between study groups at A1 and hypotensive agent discontinuation with lowest systolic blood pressure in dexmedetomidine group followed by magnesium sulfate group and then nitroglycerine group. Conclusion: nitroglycerine, magnesium sulfate and dexmedetomidine could induce hypotension, but dexmedetomidine showed more favorable hemodynamic profile as regard blood pressure and heart rate. Copies
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Comparison of the effect of nitroglycerin, magnesium sulphate and dexmedetomidine as hypotensive agents in lumbar spine surgeryAdobe Acrobat PDF
Title : The effect of ketamine as adjuvant in ultrasonic guided Supraclavicular brachial plexus block Authors: Ezzat Mahmoud EL-Soudy, Author ; Ahmed Atia Alaa Mahamed, Author ; Ali Wahed Mahamed, Author ; Ahmed Ismail Abdel Sabour, Author Publisher: Cairo [Egypt] : Pan Arab league of continuous medical education Publication Date: 2019 Series: The Egyptian Journal of Hospital Medicine, ISSN 2090-7125 No. 76(7) Pagination: p.4643-4648, fig., tab. Layout: Journal Article ISSN (or other code): 1687-2002 Languages : English Keywords: Ketamine Ultrasonics Brachial Plexus Neuritis Brachial Plexus Block Egypt – Cairo Abstract: Background: in orthopedic procedures more blood is lost from raw bone and muscle surface than from identifiable blood vessels. Moderate hypotensive anesthesia was found to significantly decrease the average blood loss by nearly 40%, reduce the need for transfusion by 45% and shorten the average operating time by nearly 10%. Objective: The aim of the current study was to compare magnesium sulphate and dexmedetomidine with nitroglycerin as regard hypotensive effect as primary outcome, volume of blood loss, blood substitution and pattern of recovery as secondary outcome during lumbar spine surgery. Patients and Methods: This prospective, controlled, comperative, randomized, double blind study included a total of ninty patients aged 21-50 years of both sex, ASA I-II scheduled for elective lumber spine surgery, attending at Department of Orthopedic, AL-Azher university Hospital in Assuit as single center study. Patients have received either dexmedetomidine, magnesium sulfate or nitroglycerine. Results: There were highly significant difference (P <0.000) with duration of surgery between different study groups with duration of surgery shortest in dexmedetomidine group followed by magnesium sulfate group and then nitroglycerine group. There were highly significant differences between different study groups with fluid maintenance with higher volume in nitroglycerine group then magnesium sulfate group and then dexmedetomidine group. There were highly significant differences (P <0.000) with systolic blood pressure between study groups at A1 and hypotensive agent discontinuation with lowest systolic blood pressure in dexmedetomidine group followed by magnesium sulfate group and then nitroglycerine group. Conclusion: nitroglycerine, magnesium sulfate and dexmedetomidine could induce hypotension, but dexmedetomidine showed more favorable hemodynamic profile as regard blood pressure and heart rate. The effect of ketamine as adjuvant in ultrasonic guided Supraclavicular brachial plexus block [] / Ezzat Mahmoud EL-Soudy, Author ; Ahmed Atia Alaa Mahamed, Author ; Ali Wahed Mahamed, Author ; Ahmed Ismail Abdel Sabour, Author . - Cairo (Egypt) : Pan Arab league of continuous medical education, 2019 . - p.4643-4648, fig., tab. : Journal Article. - (The Egyptian Journal of Hospital Medicine, ISSN 2090-7125; 76(7)) .
ISSN : 1687-2002
Languages : English
Keywords: Ketamine Ultrasonics Brachial Plexus Neuritis Brachial Plexus Block Egypt – Cairo Abstract: Background: in orthopedic procedures more blood is lost from raw bone and muscle surface than from identifiable blood vessels. Moderate hypotensive anesthesia was found to significantly decrease the average blood loss by nearly 40%, reduce the need for transfusion by 45% and shorten the average operating time by nearly 10%. Objective: The aim of the current study was to compare magnesium sulphate and dexmedetomidine with nitroglycerin as regard hypotensive effect as primary outcome, volume of blood loss, blood substitution and pattern of recovery as secondary outcome during lumbar spine surgery. Patients and Methods: This prospective, controlled, comperative, randomized, double blind study included a total of ninty patients aged 21-50 years of both sex, ASA I-II scheduled for elective lumber spine surgery, attending at Department of Orthopedic, AL-Azher university Hospital in Assuit as single center study. Patients have received either dexmedetomidine, magnesium sulfate or nitroglycerine. Results: There were highly significant difference (P <0.000) with duration of surgery between different study groups with duration of surgery shortest in dexmedetomidine group followed by magnesium sulfate group and then nitroglycerine group. There were highly significant differences between different study groups with fluid maintenance with higher volume in nitroglycerine group then magnesium sulfate group and then dexmedetomidine group. There were highly significant differences (P <0.000) with systolic blood pressure between study groups at A1 and hypotensive agent discontinuation with lowest systolic blood pressure in dexmedetomidine group followed by magnesium sulfate group and then nitroglycerine group. Conclusion: nitroglycerine, magnesium sulfate and dexmedetomidine could induce hypotension, but dexmedetomidine showed more favorable hemodynamic profile as regard blood pressure and heart rate. Copies
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Title : Randomized comparative study between direct and indirect tibial revascularization in management of critical limb ischemia Authors: Ahmed Abdelhafez, Abdelaziz, Author ; Elhayeg Omar Mokhtar, Author ; Abdel fatahHany Abd Elmomen, Author Publisher: Cairo [Egypt] : Pan Arab league of continuous medical education Publication Date: 2019 Series: The Egyptian Journal of Hospital Medicine, ISSN 2090-7125 No. 76(7) Pagination: p.1687-2002 Layout: Journal Article ISSN (or other code): 1687-2002 Languages : English Keywords: Pragmatic Clinical Trials as Topic Tibia Revascularization Disease Management ischemia Egypt – Cairo Abstract: Background: Hepatitis C virus (HCV) is a blood born virus that is considered a major cause of chronic liver disease and hepatocellular carcinoma (HCC) worldwide. HCV is thought to induce HCC either indirectly or directly by the effect of its viral proteins on different host cell proteins and signaling pathways. Objective: The aim of the study was to characterize the type of response to different HCV antigens, quantify HCV viral load, transforming growth factor- beta and miRNA 122 in patients with newly diagnosed Hepatocellular Carcinoma. Patients and methods: This study was done on three groups: the first group consisted of 40 newly discovered hepatocellular carcinoma patients with HCV infection. The second group consisted of twenty HCV infected patients with other types of cancer (other than HCC). The third group consisted of 20 healthy individuals served as a control group. Serum was separated for detection of the four parameters. Results: TGF-β showed a very weak negative correlation with the miRNA 122 serum levels that is statistically non-significant. Results also showed that miRNA 122 may not be useful in differentiating between liver cirrhosis from HCC patients and it is associated with the severity of the disease rather than the viremia count. Conclusion: Study showed no correlation between the four investigated parameters (HCV antigens, HCV viral load, TGF-β- serum levels of miRNA 122) in an attempt for early diagnosis of HCV induced HCC. Link for e-copy: https://web.b.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authty [...] Randomized comparative study between direct and indirect tibial revascularization in management of critical limb ischemia [] / Ahmed Abdelhafez, Abdelaziz, Author ; Elhayeg Omar Mokhtar, Author ; Abdel fatahHany Abd Elmomen, Author . - Cairo (Egypt) : Pan Arab league of continuous medical education, 2019 . - p.1687-2002 : Journal Article. - (The Egyptian Journal of Hospital Medicine, ISSN 2090-7125; 76(7)) .
ISSN : 1687-2002
Languages : English
Keywords: Pragmatic Clinical Trials as Topic Tibia Revascularization Disease Management ischemia Egypt – Cairo Abstract: Background: Hepatitis C virus (HCV) is a blood born virus that is considered a major cause of chronic liver disease and hepatocellular carcinoma (HCC) worldwide. HCV is thought to induce HCC either indirectly or directly by the effect of its viral proteins on different host cell proteins and signaling pathways. Objective: The aim of the study was to characterize the type of response to different HCV antigens, quantify HCV viral load, transforming growth factor- beta and miRNA 122 in patients with newly diagnosed Hepatocellular Carcinoma. Patients and methods: This study was done on three groups: the first group consisted of 40 newly discovered hepatocellular carcinoma patients with HCV infection. The second group consisted of twenty HCV infected patients with other types of cancer (other than HCC). The third group consisted of 20 healthy individuals served as a control group. Serum was separated for detection of the four parameters. Results: TGF-β showed a very weak negative correlation with the miRNA 122 serum levels that is statistically non-significant. Results also showed that miRNA 122 may not be useful in differentiating between liver cirrhosis from HCC patients and it is associated with the severity of the disease rather than the viremia count. Conclusion: Study showed no correlation between the four investigated parameters (HCV antigens, HCV viral load, TGF-β- serum levels of miRNA 122) in an attempt for early diagnosis of HCV induced HCC. Link for e-copy: https://web.b.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authty [...] Copies
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Title : Study of the effect of repetitive transcranial magnetic stimulation on a sample of children with autism spectrum disorder Authors: Ali Ismail Abd alrahman, Author ; Amgad Ahmed Moshref Gabr, Author ; Tarek Ibrahim Mohamed Elfekey, Author Publisher: Cairo [Egypt] : Pan Arab league of continuous medical education Publication Date: 2019 Series: The Egyptian Journal of Hospital Medicine, ISSN 2090-7125 No. 76(7) Pagination: p.1687-2002, tab. Layout: Journal Article ISSN (or other code): 1687-2002 Languages : English Keywords: Observational Study [Publication Type] Neurobiology Transcranial Direct Current Stimulation Autism Spectrum Disorder Egypt – Cairo Abstract: Background: Autism Spectrum Disorder (ASD) is a behaviorally defined complex neurodevelopmental syndrome. ASD is one of the most common child psychiatric disorders. Despite the long history of research on ASD, no much is known yet about the exact biological causes and how the disorder can be effectively treated. Objective: To study clinical effect of repetitive Transcranial Magnetic Stimulation (rTMS) on a sample of children with autism spectrum disorder. Patients and Methods: the sample consisted of 30 children. Their ages ranged from 4 to 10 years old. After being diagnosed clinically according to DSM-5 through a designed semi-structured interview and through application of childhood autistic rating scale CARS and assessment of the degree of clinical severity of autism spectrum disorders according to DSM-5. Results: The results of the study after the completion of 12 sessions of rTMS, there was a significant difference and improvement in the severity of the clinical symptoms for ASD except for the level of activity and listening response and use of the body by comparing the severity of symptoms before and after rTMS. Comparing results before and after rTMS by the level of clinical severity of autism according to DSM-5; at the level of severity in social communication, the improvement was statistically significant (p-value 0.001). At the level of severity in restricted and repetitive behaviors the improvement was statistically highly significant (p-value <0.001). Conclusion: this study concluded that rTMS over left dorso-lateral prefrontal cortex may be safe and effective way of providing a relief of ASD symptoms. Study of the effect of repetitive transcranial magnetic stimulation on a sample of children with autism spectrum disorder [] / Ali Ismail Abd alrahman, Author ; Amgad Ahmed Moshref Gabr, Author ; Tarek Ibrahim Mohamed Elfekey, Author . - Cairo (Egypt) : Pan Arab league of continuous medical education, 2019 . - p.1687-2002, tab. : Journal Article. - (The Egyptian Journal of Hospital Medicine, ISSN 2090-7125; 76(7)) .
ISSN : 1687-2002
Languages : English
Keywords: Observational Study [Publication Type] Neurobiology Transcranial Direct Current Stimulation Autism Spectrum Disorder Egypt – Cairo Abstract: Background: Autism Spectrum Disorder (ASD) is a behaviorally defined complex neurodevelopmental syndrome. ASD is one of the most common child psychiatric disorders. Despite the long history of research on ASD, no much is known yet about the exact biological causes and how the disorder can be effectively treated. Objective: To study clinical effect of repetitive Transcranial Magnetic Stimulation (rTMS) on a sample of children with autism spectrum disorder. Patients and Methods: the sample consisted of 30 children. Their ages ranged from 4 to 10 years old. After being diagnosed clinically according to DSM-5 through a designed semi-structured interview and through application of childhood autistic rating scale CARS and assessment of the degree of clinical severity of autism spectrum disorders according to DSM-5. Results: The results of the study after the completion of 12 sessions of rTMS, there was a significant difference and improvement in the severity of the clinical symptoms for ASD except for the level of activity and listening response and use of the body by comparing the severity of symptoms before and after rTMS. Comparing results before and after rTMS by the level of clinical severity of autism according to DSM-5; at the level of severity in social communication, the improvement was statistically significant (p-value 0.001). At the level of severity in restricted and repetitive behaviors the improvement was statistically highly significant (p-value <0.001). Conclusion: this study concluded that rTMS over left dorso-lateral prefrontal cortex may be safe and effective way of providing a relief of ASD symptoms. Copies
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