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Add the result to your basket Refine your searchIncidence of human cytomegalovirus in breast carcinoma tissues is associated with a higher expression of growth factor receptor-bound protein 2 / Mohamed Fares
Title : Incidence of human cytomegalovirus in breast carcinoma tissues is associated with a higher expression of growth factor receptor-bound protein 2 Authors: Mohamed Fares, Author ; Hossam Taha Mohamed, Author ; Sherif Abdelaziz Ibrahim, Author ; Mohamed Hosney, Author ; Mohamed I. Rady, Author ; Mohamed El-Shinawi, Author ; Mona Mostafa Mohamed, Author Publisher: Cairo [Egypt] : Pan Arab league of continuous medical education Publication Date: 2019 Series: The Egyptian Journal of Hospital Medicine, ISSN 2090-7125 No. 75(3) Pagination: p.2358-2365, fig., tab. Layout: Journal Article ISSN (or other code): 2090-7125 Languages : English Keywords: Breast Neoplasms - diagnosis Inflammatory Breast Neoplasms Cytomegalovirus GRB7 Adaptor Protein - metabolism Egypt Abstract: Background: female mammary carcinoma is the second most common cancer incidence among women and the fifth most common leading cause of cancer death worldwide. Premenopausal young women are more frequently targeted by inflammatory breast cancer (IBC), which is the most lethal form of breast cancer. The human cytomegalovirus (HCMV) has been identified as one of the viral infection with a higher frequency in carcinoma tissues of IBC than in non-IBC. The adaptor protein growth factor receptor-bound protein 2 (Grb2), was found to be upregulated in HCMV-infected cells and play as crucial role in cancer progression. Objective: this study aimed to assess the expression level of Grb2 in carcinoma tissues of IBC and non-IBC with HCMV infection. Patients and Methods: overall, 135 female diagnosed with breast carcinoma were enrolled in this study. Using conventional and real time polymerase chain reaction (PCR), we determined the incidence of HCMV and assessed the expression level of Grb2 mRNA in the breast cancer tissue samples. Results: Grb2 mRNA was significantly upregulated in HCMV+ IBC higher than in HCMV+ non-IBC. According to the molecular subtype, Grb2 mRNA was significantly higher upregulated in breast carcinoma tissues of HCMV+ hormonal positive (HP) than in triple negative (TN) counterparts. Conclusion: HCMV infection is associated with a high expression of Grb2 mRNA in IBC and that HP HCMV+ mammary carcinoma tissues confer upregulated Grb2 mRNA, suggesting a potential role of HCMV infection in enhancing of Grb2 mRNA expression in breast cancer with HP. Incidence of human cytomegalovirus in breast carcinoma tissues is associated with a higher expression of growth factor receptor-bound protein 2 [] / Mohamed Fares, Author ; Hossam Taha Mohamed, Author ; Sherif Abdelaziz Ibrahim, Author ; Mohamed Hosney, Author ; Mohamed I. Rady, Author ; Mohamed El-Shinawi, Author ; Mona Mostafa Mohamed, Author . - Cairo (Egypt) : Pan Arab league of continuous medical education, 2019 . - p.2358-2365, fig., tab. : Journal Article. - (The Egyptian Journal of Hospital Medicine, ISSN 2090-7125; 75(3)) .
ISSN : 2090-7125
Languages : English
Keywords: Breast Neoplasms - diagnosis Inflammatory Breast Neoplasms Cytomegalovirus GRB7 Adaptor Protein - metabolism Egypt Abstract: Background: female mammary carcinoma is the second most common cancer incidence among women and the fifth most common leading cause of cancer death worldwide. Premenopausal young women are more frequently targeted by inflammatory breast cancer (IBC), which is the most lethal form of breast cancer. The human cytomegalovirus (HCMV) has been identified as one of the viral infection with a higher frequency in carcinoma tissues of IBC than in non-IBC. The adaptor protein growth factor receptor-bound protein 2 (Grb2), was found to be upregulated in HCMV-infected cells and play as crucial role in cancer progression. Objective: this study aimed to assess the expression level of Grb2 in carcinoma tissues of IBC and non-IBC with HCMV infection. Patients and Methods: overall, 135 female diagnosed with breast carcinoma were enrolled in this study. Using conventional and real time polymerase chain reaction (PCR), we determined the incidence of HCMV and assessed the expression level of Grb2 mRNA in the breast cancer tissue samples. Results: Grb2 mRNA was significantly upregulated in HCMV+ IBC higher than in HCMV+ non-IBC. According to the molecular subtype, Grb2 mRNA was significantly higher upregulated in breast carcinoma tissues of HCMV+ hormonal positive (HP) than in triple negative (TN) counterparts. Conclusion: HCMV infection is associated with a high expression of Grb2 mRNA in IBC and that HP HCMV+ mammary carcinoma tissues confer upregulated Grb2 mRNA, suggesting a potential role of HCMV infection in enhancing of Grb2 mRNA expression in breast cancer with HP. Copies
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Title : Patients risk factors as predictors of surgical wound infection following open heart surgery Authors: Ahmed M. El Ashkar, Author ; Ahmed N. Khallaf, Author Publisher: Cairo [Egypt] : Pan Arab league of continuous medical education Publication Date: 2019 Series: The Egyptian Journal of Hospital Medicine, ISSN 2090-7125 Pagination: p.2330-2333, tab. Layout: Journal Article ISSN (or other code): 2090-7125 Languages : English Keywords: Cardiac Surgical Procedures Heart Diseases - surgery Surgical Wound Infection Risk Factors Egypt - Fayoum Abstract: Background: Median sternotomy wound infections are infrequent yet potentially fatal complication following cardiac surgery. The reported incidence of sternal infections ranges from 0.9 to 20%, and the incidence of mediastinitis is 1–2% in most studies. Several studies have examined and identified possible causes and risk factors associated with sternal infections. They include patient-related risk factors, and procedure-related factors. Aim of the study is the assessment of the patient’s risk factors related to incidence of infection. Patients and Methods: ninety-eight cardiac surgery patients operated via median sternotomy were included in the study and the role of patient related factors (age, gender, obesity and diabetes mellitus) in the incidence of postoperative superficial and deep sternal wound infection was accessed. Results: Sternal wound infection (SWI) developed in 18 patients (18.36%). 15 patients (15.3%) had superficial SWI while 3 patients (3.06%) had deep SWI. The most common causative organism in our study was staph. aureus especially MRSA.Conclusion: Patient-related risk factors such as age, gender, obesity and diabetes mellitus are important risk factors in the development sternal wound infection. Patients risk factors as predictors of surgical wound infection following open heart surgery [] / Ahmed M. El Ashkar, Author ; Ahmed N. Khallaf, Author . - Cairo (Egypt) : Pan Arab league of continuous medical education, 2019 . - p.2330-2333, tab. : Journal Article. - (The Egyptian Journal of Hospital Medicine, ISSN 2090-7125) .
ISSN : 2090-7125
Languages : English
Keywords: Cardiac Surgical Procedures Heart Diseases - surgery Surgical Wound Infection Risk Factors Egypt - Fayoum Abstract: Background: Median sternotomy wound infections are infrequent yet potentially fatal complication following cardiac surgery. The reported incidence of sternal infections ranges from 0.9 to 20%, and the incidence of mediastinitis is 1–2% in most studies. Several studies have examined and identified possible causes and risk factors associated with sternal infections. They include patient-related risk factors, and procedure-related factors. Aim of the study is the assessment of the patient’s risk factors related to incidence of infection. Patients and Methods: ninety-eight cardiac surgery patients operated via median sternotomy were included in the study and the role of patient related factors (age, gender, obesity and diabetes mellitus) in the incidence of postoperative superficial and deep sternal wound infection was accessed. Results: Sternal wound infection (SWI) developed in 18 patients (18.36%). 15 patients (15.3%) had superficial SWI while 3 patients (3.06%) had deep SWI. The most common causative organism in our study was staph. aureus especially MRSA.Conclusion: Patient-related risk factors such as age, gender, obesity and diabetes mellitus are important risk factors in the development sternal wound infection. Copies
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Patients risk factors as predictors of surgical wound infection following open heart surgeryAdobe Acrobat PDF
Title : Vitamin B12 status among pregnant women and Its association with obesity and gestational diabetes Authors: Mohammed Mohammed Gebril, Author ; Tarek Ramadan Abbas, Author ; Mohammad Saad Eldeen Radwan, Author ; Mustafa Mohammed Abd El-Kader, Author Publisher: Cairo [Egypt] : Pan Arab league of continuous medical education Publication Date: 2019 Series: The Egyptian Journal of Hospital Medicine, ISSN 2090-7125 No. 75(3) Pagination: p.2381-2388 Layout: Journal Article ISSN (or other code): 2090-7125 Languages : English Keywords: Vitamin B 12 Deficiency Pregnant Women Diabetes, Gestational Obesity Egypt Abstract: Background: pregnant women in resource-poor areas are at risk of multiple micronutrient deficiencies, and diets that are low in animal products place women at increased risk of vitamin B12 deficiency. Aim of the Work: to investigate the vitamin B12 status of pregnant women in Egypt and its relationship with obesity and gestational diabetes mellitus (GDM). Patients and Methods: this clinical observational prospective study has been conducted at Bab Al-Shaaria University Hospital Obstetrics and Gynecological Department from April 2018 to January 2019. To assess vitamin B12 status among pregnant woman and its association with obesity and gestational diabetes. 80 pregnant women attended to out-patient clinic were included in the study. The evaluation included data collection through: history taking, examination, anthropometric measurement, maternal blood vitamin B12 level estimation at second and third trimester and blood glucose level. Results: vitamin B12 deficiency in pregnancy is common particularly in obese women and those with GDM. Conclusion: vitamin B12 deficiency is silent and common in general population. Causes of vitamin B12 deficiencies are multifactorial and associated with many health problems. Also, obesity is common and its prevalence is increasing in the world. Therefore, both health problems have gained importance in family medicine practice in the last decades. Vitamin B12 status among pregnant women and Its association with obesity and gestational diabetes [] / Mohammed Mohammed Gebril, Author ; Tarek Ramadan Abbas, Author ; Mohammad Saad Eldeen Radwan, Author ; Mustafa Mohammed Abd El-Kader, Author . - Cairo (Egypt) : Pan Arab league of continuous medical education, 2019 . - p.2381-2388 : Journal Article. - (The Egyptian Journal of Hospital Medicine, ISSN 2090-7125; 75(3)) .
ISSN : 2090-7125
Languages : English
Keywords: Vitamin B 12 Deficiency Pregnant Women Diabetes, Gestational Obesity Egypt Abstract: Background: pregnant women in resource-poor areas are at risk of multiple micronutrient deficiencies, and diets that are low in animal products place women at increased risk of vitamin B12 deficiency. Aim of the Work: to investigate the vitamin B12 status of pregnant women in Egypt and its relationship with obesity and gestational diabetes mellitus (GDM). Patients and Methods: this clinical observational prospective study has been conducted at Bab Al-Shaaria University Hospital Obstetrics and Gynecological Department from April 2018 to January 2019. To assess vitamin B12 status among pregnant woman and its association with obesity and gestational diabetes. 80 pregnant women attended to out-patient clinic were included in the study. The evaluation included data collection through: history taking, examination, anthropometric measurement, maternal blood vitamin B12 level estimation at second and third trimester and blood glucose level. Results: vitamin B12 deficiency in pregnancy is common particularly in obese women and those with GDM. Conclusion: vitamin B12 deficiency is silent and common in general population. Causes of vitamin B12 deficiencies are multifactorial and associated with many health problems. Also, obesity is common and its prevalence is increasing in the world. Therefore, both health problems have gained importance in family medicine practice in the last decades. Copies
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Vitamin B12 status among pregnant women and Its association with obesity and gestational diabetesAdobe Acrobat PDF
Title : A critique of proposed strategies for tackling female obesity in Egypt Authors: Raouf Alebshehy, Author ; Josephine Ohas, Author Publisher: Cairo [Egypt] : Pan Arab league of continuous medical education Publication Date: 2017 Series: The Egyptian Journal of Hospital Medicine, ISSN 2090-7125 No. 66 Pagination: p.18-27, Layout: Journal Article ISSN (or other code): 2090-7125 Languages : French Keywords: Obesity - prevention&control Obesity - etiology Prevalence Healthy Lifestyle Exercise Health Promotion Women Egypt Abstract: Background: obesity is a huge health problem in Egypt. Its prevalence is the double among Egyptian females as compared to males. It is estimated that 75% of females over the age of thirty are overweight or obese. However, 95% of Egyptian females are not taking any measures to control their weight; additionally there is no national program to address the problem. Methods: following specific appraisal criteria, this research article provides a critical appraisal of strategies that could help in addressing the problem of obesity among females. This article includes an appraisal of interventions of promoting healthy lifestyle changes; healthy diet and physical activity. It also provides an appraisal of using social media, primary healthcare clinics, and pharmacies as delivery strategies of the proposed interventions. Findings: the research article reveals the feasibility of the proposed strategies based on the criteria of effectiveness, cost-effectiveness, organizational feasibility, and gender appropriateness.
A critique of proposed strategies for tackling female obesity in Egypt [] / Raouf Alebshehy, Author ; Josephine Ohas, Author . - Cairo (Egypt) : Pan Arab league of continuous medical education, 2017 . - p.18-27, : Journal Article. - (The Egyptian Journal of Hospital Medicine, ISSN 2090-7125; 66) .
ISSN : 2090-7125
Languages : French
Keywords: Obesity - prevention&control Obesity - etiology Prevalence Healthy Lifestyle Exercise Health Promotion Women Egypt Abstract: Background: obesity is a huge health problem in Egypt. Its prevalence is the double among Egyptian females as compared to males. It is estimated that 75% of females over the age of thirty are overweight or obese. However, 95% of Egyptian females are not taking any measures to control their weight; additionally there is no national program to address the problem. Methods: following specific appraisal criteria, this research article provides a critical appraisal of strategies that could help in addressing the problem of obesity among females. This article includes an appraisal of interventions of promoting healthy lifestyle changes; healthy diet and physical activity. It also provides an appraisal of using social media, primary healthcare clinics, and pharmacies as delivery strategies of the proposed interventions. Findings: the research article reveals the feasibility of the proposed strategies based on the criteria of effectiveness, cost-effectiveness, organizational feasibility, and gender appropriateness.
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Title : Review article: risk factors for non-communicable diseases in Libya Authors: Nura N. Altajori, Author ; Yousef M. Elshrek, Author Publisher: Cairo [Egypt] : Pan Arab league of continuous medical education Publication Date: 2017 Series: The Egyptian Journal of Hospital Medicine, ISSN 2090-7125 No. 66 Pagination: p.202-214 Layout: Journal Article ISSN (or other code): 2090-7125 Languages : French Keywords: Chronic Disease Obesity Cardiovascular Diseases Diabetes Mellitus Hypertension Libya Abstract: This review article highlights the current situation of some non-communicable diseases in Libya and factors contributing to its prevalence such as obesity, diabetes, cardiovascular diseases (CVD), high blood pressure and cancer. Obesity is a global epidemic resulting in major morbidity and premature death. Between 26-41% among adult Libyan women and 11¬21 % among adult Libyan men (about 64% of Libyan adults are either overweight or obese), obesity progressively increasing with age, and two times more common among Libyan women than men. Hypertension is a common co-morbidity of diabetes, affecting 20-60% of people with diabetes. Hypertension is also a major risk factor for CVD as well as microvascular complications such as retinopathy and nephropathy. About 68.4% of Libyan males and 48.4 % of Libyan females who suffer from high blood pressure are under treatment. The average rate of those who suffer from diabetes mellitus among Libyans reached between 11 ¬ 23.3 % for both sexes. The main causes of death are cardiovascular diseases (43%), cancer (14%), chronic respiratory diseases (4%), diabetes (5%), other Non-communicable diseases (NCDs) (12%), communicable maternal perinatal and nutritional conditions (10%), and road traffic injuries (12%). The prevalence of risk factors for non-communicable diseases has risen as a result of changing lifestyles. More than 30% of the adult male population smokes regularly. Approximately, 1.2 percent of the population is blind, mainly due to cataract. Trachoma remains endemic in some pockets in the country. Road traffic crashes, which result in 6 deaths per day and even higher figures for disability, account for a significant burden of disease
Review article: risk factors for non-communicable diseases in Libya [] / Nura N. Altajori, Author ; Yousef M. Elshrek, Author . - Cairo (Egypt) : Pan Arab league of continuous medical education, 2017 . - p.202-214 : Journal Article. - (The Egyptian Journal of Hospital Medicine, ISSN 2090-7125; 66) .
ISSN : 2090-7125
Languages : French
Keywords: Chronic Disease Obesity Cardiovascular Diseases Diabetes Mellitus Hypertension Libya Abstract: This review article highlights the current situation of some non-communicable diseases in Libya and factors contributing to its prevalence such as obesity, diabetes, cardiovascular diseases (CVD), high blood pressure and cancer. Obesity is a global epidemic resulting in major morbidity and premature death. Between 26-41% among adult Libyan women and 11¬21 % among adult Libyan men (about 64% of Libyan adults are either overweight or obese), obesity progressively increasing with age, and two times more common among Libyan women than men. Hypertension is a common co-morbidity of diabetes, affecting 20-60% of people with diabetes. Hypertension is also a major risk factor for CVD as well as microvascular complications such as retinopathy and nephropathy. About 68.4% of Libyan males and 48.4 % of Libyan females who suffer from high blood pressure are under treatment. The average rate of those who suffer from diabetes mellitus among Libyans reached between 11 ¬ 23.3 % for both sexes. The main causes of death are cardiovascular diseases (43%), cancer (14%), chronic respiratory diseases (4%), diabetes (5%), other Non-communicable diseases (NCDs) (12%), communicable maternal perinatal and nutritional conditions (10%), and road traffic injuries (12%). The prevalence of risk factors for non-communicable diseases has risen as a result of changing lifestyles. More than 30% of the adult male population smokes regularly. Approximately, 1.2 percent of the population is blind, mainly due to cataract. Trachoma remains endemic in some pockets in the country. Road traffic crashes, which result in 6 deaths per day and even higher figures for disability, account for a significant burden of disease
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